A neurocomputational hypothesis for nicotine addiction.
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ABSTRACT:
SUBMITTER: Gutkin BS
PROVIDER: S-EPMC1348008 | biostudies-other | 2006 Jan
REPOSITORIES: biostudies-other
Publications
A neurocomputational hypothesis for nicotine addiction.
Gutkin Boris S BS Dehaene Stanislas S Changeux Jean-Pierre JP
Proceedings of the National Academy of Sciences of the United States of America 20060113 4
We present a hypothetical neurocomputational model that combines a set of neural circuits at the molecular, cellular, and system levels and accounts for several neurobiological and behavioral processes leading to nicotine addiction. We propose that combining changes in the nicotinic receptor response, expressed by mesolimbic dopaminergic neurons, with dopamine-gated learning in action-selection circuits, suffices to capture the acquisition of nicotine addiction. We show that an opponent process ...[more]
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