Ontology highlight
ABSTRACT:
SUBMITTER: Guthridge MA
PROVIDER: S-EPMC1383532 | biostudies-other | 2006 Feb
REPOSITORIES: biostudies-other
Guthridge Mark A MA Powell Jason A JA Barry Emma F EF Stomski Frank C FC McClure Barbara J BJ Ramshaw Hayley H Felquer Fernando A FA Dottore Mara M Thomas Daniel T DT To Bik B Begley C Glenn CG Lopez Angel F AF
The EMBO journal 20060126 3
Pleiotropism is a hallmark of cytokines and growth factors; yet, the underlying mechanisms are not clearly understood. We have identified a motif in the granulocyte macrophage-colony-stimulating factor receptor composed of a tyrosine and a serine residue that functions as a binary switch for the independent regulation of multiple biological activities. Signalling occurs either through Ser585 at lower cytokine concentrations, leading to cell survival only, or through Tyr577 at higher cytokine con ...[more]