Ontology highlight
ABSTRACT:
SUBMITTER: Tourovskaia A
PROVIDER: S-EPMC1386797 | biostudies-other | 2006 Mar
REPOSITORIES: biostudies-other
Biophysical journal 20051230 6
During neuromuscular synaptogenesis, the exchange of spatially localized signals between nerve and muscle initiates the coordinated focal accumulation of the acetylcholine (ACh) release machinery and the ACh receptors (AChRs). One of the key first steps is the release of the proteoglycan agrin focalized at the axon tip, which induces the clustering of AChRs on the postsynaptic membrane at the neuromuscular junction. The lack of a suitable method for focal application of agrin in myotube cultures ...[more]