Ontology highlight
ABSTRACT:
SUBMITTER: Ozturk N
PROVIDER: S-EPMC1413736 | biostudies-other | 2006 Feb
REPOSITORIES: biostudies-other
Ozturk Nuri N Erdal Esra E Mumcuoglu Mine M Akcali Kamil C KC Yalcin Ozden O Senturk Serif S Arslan-Ergul Ayca A Gur Bala B Yulug Isik I Cetin-Atalay Rengul R Yakicier Cengiz C Yagci Tamer T Tez Mesut M Ozturk Mehmet M
Proceedings of the National Academy of Sciences of the United States of America 20060206 7
Tumor cells have the capacity to proliferate indefinitely that is qualified as replicative immortality. This ability contrasts with the intrinsic control of the number of cell divisions in human somatic tissues by a mechanism called replicative senescence. Replicative immortality is acquired by inactivation of p53 and p16INK4a genes and reactivation of hTERT gene expression. It is unknown whether the cancer cell replicative immortality is reversible. Here, we show the spontaneous induction of re ...[more]