Ontology highlight
ABSTRACT:
SUBMITTER: Connert S
PROVIDER: S-EPMC1440832 | biostudies-other | 2006 Apr
REPOSITORIES: biostudies-other
Connert Sabine S Wienand Simone S Thiel Cora C Krikunova Maria M Glyvuk Nataliya N Tsytsyura Yaroslav Y Hilfiker-Kleiner Denise D Bartsch Jörg W JW Klingauf Jürgen J Wienands Jürgen J
The EMBO journal 20060406 8
The intracellular adaptor protein SH3P7 is the mammalian ortholog of yeast actin-binding protein 1 and thus alternatively named as mAbp1 (or HIP55). Structural properties, biochemical analysis of its interaction partners and siRNA studies implicated mAbp1 as an accessory protein in clathrin-mediated endocytosis (CME). Here, we describe the generation and characterization of mice deficient for SH3P7/mAbp1 owing to targeted gene disruption in embryonic stem cells. Mutant animals are viable and fer ...[more]