Ontology highlight
ABSTRACT:
SUBMITTER: Laurencikiene J
PROVIDER: S-EPMC1456888 | biostudies-other | 2006 Mar
REPOSITORIES: biostudies-other
Laurencikiene Jurga J Källman Annika M AM Fong Nova N Bentley David L DL Ohman Marie M
EMBO reports 20060127 3
The carboxy-terminal domain (CTD) of the large subunit of RNA polymerase II (pol II) is essential for several co-transcriptional pre-messenger RNA processing events, including capping, 3'-end processing and splicing. We investigated the role of the CTD of RNA pol II in the coordination of A to I editing and splicing of the ADAR2 (ADAR: adenosine deaminases that act on RNA) pre-mRNA. The auto-editing of Adar2 intron 4 by the ADAR2 adenosine deaminase is tightly coupled to splicing, as the modific ...[more]