Ontology highlight
ABSTRACT:
SUBMITTER: Bouwer HG
PROVIDER: S-EPMC1458801 | biostudies-other | 2006 Mar
REPOSITORIES: biostudies-other
Bouwer H G Archie HG Alberti-Segui Christine C Montfort Megan J MJ Berkowitz Nathan D ND Higgins Darren E DE
Proceedings of the National Academy of Sciences of the United States of America 20060320 13
We have developed a vaccine strategy for generating an attenuated strain of an intracellular bacterial pathogen that, after uptake by professional antigen-presenting cells, does not replicate intracellularly and is readily killed. However, after degradation of the vaccine strain within the phagolysosome, target antigens are released into the cytosol for endogenous processing and presentation for stimulation of CD8(+) effector T cells. Applying this strategy to the model intracellular pathogen Li ...[more]