Ontology highlight
ABSTRACT:
SUBMITTER: Schubart DB
PROVIDER: S-EPMC145881 | biostudies-other | 1996 May
REPOSITORIES: biostudies-other
Schubart D B DB Sauter P P Massa S S Friedl E M EM Schwarzenbach H H Matthias P P
Nucleic acids research 19960501 10
The B cell-specific activity of immunoglobulin (Ig) gene promoters is to a large extent mediated by the conserved octamer motif ATTTGCAT. This requires the DNA binding octamer factors Oct-1 and/or Oct-2, as well as an additional B cell-restricted non-DNA binding cofactor. We recently cloned such a coactivator specific for Oct-1 or Oct-2 from human B cells and called it OBF-1. Here we report the isolation and characterization of the murine homologue. Full-length cDNA clones as well as genomic clo ...[more]