Ontology highlight
ABSTRACT:
SUBMITTER: Whalen WA
PROVIDER: S-EPMC1460645 | biostudies-other | 1999 Jul
REPOSITORIES: biostudies-other
Whalen W A WA Yoon J H JH Shen R R Dhar R R
Genetics 19990701 3
We have isolated a mutation in nup184(nup184-1) that is synthetically lethal with the mRNA export defective rae1-167 mutation in Schizosaccharomyces pombe. The consequence of the synthetic lethality is a defect in mRNA export. The predicted Nup184p is similar to Nup188p of Saccharomyces cerevisiae, and a Nup184p-GFP fusion localizes to the nuclear periphery in a punctate pattern. The Deltanup184 null mutant is viable and also is synthetically lethal with rae1-167. In a rae1(+) background, both t ...[more]