Ontology highlight
ABSTRACT:
SUBMITTER: Yang P
PROVIDER: S-EPMC1461145 | biostudies-other | 2000 Jul
REPOSITORIES: biostudies-other
Yang P P Shaver S A SA Hilliker A J AJ Sokolowski M B MB
Genetics 20000701 3
Our genetic dissection of behavior has isolated scribbler (sbb), a vital gene that encodes a novel protein expressed in the embryonic and larval nervous systems and in the imaginal discs. Larvae with mutations in sbb exhibit abnormally high amounts of turning behavior in the absence of food. sbb is a large gene spanning >50 kb of genomic DNA with four major developmentally regulated transcripts. Transgenic rescue of scribbler behavior was demonstrated by targeting expression of a normal sbb tran ...[more]