Ontology highlight
ABSTRACT:
SUBMITTER: Niessen M
PROVIDER: S-EPMC1461513 | biostudies-other | 2001 Feb
REPOSITORIES: biostudies-other
Niessen M M Schneiter R R Nothiger R R
Genetics 20010201 2
Sex-lethal (Sxl) is a central switch gene in somatic sexual development of Drosophila melanogaster. Female-specific expression of Sxl relies on autoregulatory splicing of Sxl pre-mRNA by SXL protein. This process requires the function of virilizer (vir). Besides its role in Sxl splicing, vir is essential for male and female viability and is also required for the production of eggs capable of embryonic development. We have identified vir molecularly and found that it produces a single transcript ...[more]