Ontology highlight
ABSTRACT:
SUBMITTER: Browning VL
PROVIDER: S-EPMC1461990 | biostudies-other | 2002 Feb
REPOSITORIES: biostudies-other
Browning Victoria L VL Bergstrom Rebecca A RA Daigle Sandra S Schimenti John C JC
Genetics 20020201 2
Proper levels of gene expression are important for normal mammalian development. Typically, altered gene dosage caused by karyotypic abnormalities results in embryonic lethality or birth defects. Segmental aneuploidy can be compatible with life but often results in contiguous gene syndromes. The ability to manipulate the mouse genome allows the systematic exploration of regions that are affected by alterations in gene dosage. To explore the effects of segmental haploidy in the mouse t complex on ...[more]