Evolutionary, structural and biochemical evidence for a new interaction site of the leptin obesity protein.
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ABSTRACT:
SUBMITTER: Gaucher EA
PROVIDER: S-EPMC1462526 | biostudies-other | 2003 Apr
REPOSITORIES: biostudies-other
Publications
Evolutionary, structural and biochemical evidence for a new interaction site of the leptin obesity protein.
Gaucher Eric A EA Miyamoto Michael M MM Benner Steven A SA
Genetics 20030401 4
The Leptin protein is central to the regulation of energy metabolism in mammals. By integrating evolutionary, structural, and biochemical information, a surface segment, outside of its known receptor contacts, is predicted as a second interaction site that may help to further define its roles in energy balance and its functional differences between humans and other mammals. ...[more]
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