Allele frequency-based analyses robustly map sequence sites under balancing selection in a malaria vaccine candidate antigen.
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ABSTRACT:
SUBMITTER: Polley SD
PROVIDER: S-EPMC1462796 | biostudies-other | 2003 Oct
REPOSITORIES: biostudies-other
Publications
Allele frequency-based analyses robustly map sequence sites under balancing selection in a malaria vaccine candidate antigen.
Polley Spencer D SD Chokejindachai Watcharee W Conway David J DJ
Genetics 20031001 2
The Plasmodium falciparum apical membrane antigen 1 (AMA1) is a leading candidate for a malaria vaccine. Here, within-population analyses of alleles from 50 Thai P. falciparum isolates yield significant evidence for balancing selection on polymorphisms within the disulfide-bonded domains I and III of the surface accessible ectodomain of AMA1, a result very similar to that seen previously in a Nigerian population. Studying the frequency of nucleotide polymorphisms in both populations shows that t ...[more]
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