Ontology highlight
ABSTRACT:
SUBMITTER: Huhn P
PROVIDER: S-EPMC146445 | biostudies-other | 1997 Jan
REPOSITORIES: biostudies-other
Hühn P P Pruijn G J GJ van Venrooij W J WJ Bachmann M M
Nucleic acids research 19970101 2
During the analysis of the La (SS-B) autoantigen for catalytic activities an ATP-dependent double-stranded RNA unwinding activity was detected. Both native and recombinant La proteins from different species displayed this activity, which could be inhibited by monospecific anti-La antibodies. La protein was able to melt dsRNA substrates with either two 3'-overhangs or a single 3'- and a 5'-overhang. Double-stranded RNAs with two 5'-overhangs were not unwound, indicating that at least one 3'-overh ...[more]