Ontology highlight
ABSTRACT:
SUBMITTER: Lowe TM
PROVIDER: S-EPMC146525 | biostudies-other | 1997 Mar
REPOSITORIES: biostudies-other
Nucleic acids research 19970301 5
We describe a program, tRNAscan-SE, which identifies 99-100% of transfer RNA genes in DNA sequence while giving less than one false positive per 15 gigabases. Two previously described tRNA detection programs are used as fast, first-pass prefilters to identify candidate tRNAs, which are then analyzed by a highly selective tRNA covariance model. This work represents a practical application of RNA covariance models, which are general, probabilistic secondary structure profiles based on stochastic c ...[more]