Ontology highlight
ABSTRACT:
SUBMITTER: Kumar S
PROVIDER: S-EPMC147317 | biostudies-other | 1998 Feb
REPOSITORIES: biostudies-other
Kumar S S Reed M W MW Gamper H B HB Gorn V V VV Lukhtanov E A EA Foti M M West J J Meyer R B RB Schweitzer B I BI
Nucleic acids research 19980201 3
The tripeptide 1,2-dihydro-(3 H )-pyrrolo[3,2- e ]indole-7-carboxylate (CDPI3) binds to the minor groove of DNA with high affinity. When this minor groove binder is conjugated to the 5'-end of short oligonucleotides the conjugates form unusually stable hybrids with complementary DNA and thus may have useful diagnostic and/or therapeutic applications. In order to gain an understanding of the structural interactions between the CDPI3minor groove binding moiety and the DNA, we have determined and c ...[more]