Analyzing genomes with cumulative skew diagrams.
Ontology highlight
ABSTRACT:
SUBMITTER: Grigoriev A
PROVIDER: S-EPMC147580 | biostudies-other | 1998 May
REPOSITORIES: biostudies-other
Publications
A novel method of cumulative diagrams shows that the nucleotide composition of a microbial chromosome changes at two points separated by about a half of its length. These points coincide with sites of replication origin and terminus for all bacteria where such sites are known. The leading strand is found to contain more guanine than cytosine residues. This fact is used to predict origin and terminus locations in other bacterial and archaeal genomes. Local changes, visible as diagram distortions, ...[more]
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