Ontology highlight
ABSTRACT:
SUBMITTER: Garcia-Dominguez M
PROVIDER: S-EPMC1478176 | biostudies-other | 2006 Jun
REPOSITORIES: biostudies-other
Garcia-Dominguez Mario M Gilardi-Hebenstreit Pascale P Charnay Patrick P
The EMBO journal 20060504 11
The zinc-finger transcription factor Krox20 constitutes a key regulator of hindbrain development, essential for the formation and specification of rhombomeres (r) 3 and 5. It is in particular responsible for the respective activation and repression of odd- and even-numbered rhombomere-specific genes, which include Hox genes. In this study, we have identified PIASxbeta as a novel direct interactor of Krox20. In addition, we found that PIASxbeta is able to activate the r4-specific gene Hoxb1. Bind ...[more]