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From head to toes: the multiple facets of Sox proteins.

ABSTRACT: Sox proteins belong to the HMG box superfamily of DNA-binding proteins and are found throughout the animal kingdom. They are involved in the regulation of such diverse developmental processes as germ layer formation, organ development and cell type specifi-cation. Hence, deletion or mutation of Sox proteins often results in developmental defects and congenital disease in humans. Sox proteins perform their function in a complex interplay with other transcription factors in a manner highly dependent on cell type and promoter context. They exhibit a remarkable crosstalk and functional redundancy among each other.

SUBMITTER: Wegner M

PROVIDER: S-EPMC148332 | biostudies-other | 1999 Mar

REPOSITORIES: biostudies-other

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From head to toes: the multiple facets of Sox proteins.

Wegner M M

Nucleic acids research 19990301 6

Sox proteins belong to the HMG box superfamily of DNA-binding proteins and are found throughout the animal kingdom. They are involved in the regulation of such diverse developmental processes as germ layer formation, organ development and cell type specifi-cation. Hence, deletion or mutation of Sox proteins often results in developmental defects and congenital disease in humans. Sox proteins perform their function in a complex interplay with other transcription factors in a manner highly depende ...[more]

PMID: 10037800

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