Ontology highlight
ABSTRACT:
SUBMITTER: Vetsch M
PROVIDER: S-EPMC1500831 | biostudies-other | 2006 Jul
REPOSITORIES: biostudies-other
Vetsch Michael M Erilov Denis D Molière Noël N Nishiyama Mireille M Ignatov Oleksandr O Glockshuber Rudi R
EMBO reports 20060609 7
The chaperone-usher pathway directs the formation of adhesive surface fibres in numerous pathogenic Gram-negative bacteria. The fibres or pili consist exclusively of protein subunits that, before assembly, form transient complexes with a chaperone in the periplasm. In these chaperone:subunit complexes, the chaperone donates one beta-strand to complete the imperfect immunoglobulin-like fold of the subunit. During pilus assembly, the chaperone is replaced by a polypeptide extension of another subu ...[more]