Ontology highlight
ABSTRACT:
SUBMITTER: Markiewicz E
PROVIDER: S-EPMC1523183 | biostudies-other | 2006 Jul
REPOSITORIES: biostudies-other
Markiewicz Ewa E Tilgner Katarzyna K Barker Nick N van de Wetering Mark M Clevers Hans H Dorobek Margareth M Hausmanowa-Petrusewicz Irena I Ramaekers Frans C S FC Broers Jos L V JL Blankesteijn W Matthijs WM Salpingidou Georgia G Wilson Robert G RG Ellis Juliet A JA Hutchison Christopher J CJ
The EMBO journal 20060720 14
Emerin is a type II inner nuclear membrane (INM) protein of unknown function. Emerin function is likely to be important because, when it is mutated, emerin promotes both skeletal muscle and heart defects. Here we show that one function of Emerin is to regulate the flux of beta-catenin, an important transcription coactivator, into the nucleus. Emerin interacts with beta-catenin through a conserved adenomatous polyposis coli (APC)-like domain. When GFP-emerin is expressed in HEK293 cells, beta-cat ...[more]