Ontology highlight
ABSTRACT:
SUBMITTER: Mandell JG
PROVIDER: S-EPMC1538883 | biostudies-other | 2006 Jul
REPOSITORIES: biostudies-other
Nucleic acids research 20060701 Web Server issue
Individual zinc finger (ZF) domains that recognize DNA triplets with high specificity and affinity can be used to create designer transcription factors and nucleases that are specific for nearly any site in the genome. These domains can be treated as modular units and assembled to create a polydactyl protein that recognizes extended DNA sequences. Deter-mination of valid target sites and the subsequent design of ZF proteins (ZFPs) is error-prone and not trivial, however. As a result, the use of ...[more]