Molecular cloning and characterization of rat P2Y4 nucleotide receptor.
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ABSTRACT:
SUBMITTER: Bogdanov YD
PROVIDER: S-EPMC1565425 | biostudies-other | 1998 Jun
REPOSITORIES: biostudies-other
Publications
Molecular cloning and characterization of rat P2Y4 nucleotide receptor.
Bogdanov Y D YD Wildman S S SS Clements M P MP King B F BF Burnstock G G
British journal of pharmacology 19980601 3
An intronless open reading frame encoding a protein (361aa in length) was isolated from a rat genomic library probed with a DNA fragment from rat heart. This protein showed 83% sequence identity with the human P2Y4 (hP2Y4) receptor and represents a homologue of the human pyrimidinoceptor. However, the rP2Y4 receptor is not selective for uridine nucleotides and, instead, shows an agonist potency order of ITP = ATP = ADP(pure) = UTP = ATPgammaS = 2-MeSATP = Ap4A > UDP(pure). ADP, ATPgammaS, 2-MeSA ...[more]
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