Intricacies and surprises of nuclear-mitochondrial co-evolution.
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ABSTRACT: In this issue of the Biochemical Journal, Watanabe and colleagues disclose another fascinating facet of the mitochondrial protein synthesis machinery: one of the two nematode mitochondrial elongation factors Tu, EF-Tu1, specifically recognizes the D-arm of T-armless tRNAs via a 57-amino-acid C-terminal extension that compensates for the reduction in tRNA structure. This principle provides a paradigm for the evolutionary events thought to have ignited the transition from an ancient 'RNA world' to the 'protein world' of today.
SUBMITTER: Willkomm DK
PROVIDER: S-EPMC1609910 | biostudies-other | 2006 Oct
REPOSITORIES: biostudies-other
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