Ontology highlight
ABSTRACT:
SUBMITTER: Huang YS
PROVIDER: S-EPMC1618119 | biostudies-other | 2006 Oct
REPOSITORIES: biostudies-other
Huang Yi-Shuian YS Kan Ming-Chung MC Lin Chien-Ling CL Richter Joel D JD
The EMBO journal 20061005 20
CPEB is a sequence-specific RNA-binding protein that promotes polyadenylation-induced translation in oocytes and neurons. Vertebrates contain three additional genes that encode CPEB-like proteins, all of which are expressed in the brain. Here, we use SELEX, RNA structure probing, and RNA footprinting to show that CPEB and the CPEB-like proteins interact with different RNA sequences and thus constitute different classes of RNA-binding proteins. In transfected neurons, CPEB3 represses the translat ...[more]