Ontology highlight
ABSTRACT:
SUBMITTER: Cai Y
PROVIDER: S-EPMC1630492 | biostudies-other | 2006 Nov
REPOSITORIES: biostudies-other
Cai Yunfei Y Biais Nicolas N Giannone Gregory G Tanase Monica M Jiang Guoying G Hofman Jake M JM Wiggins Chris H CH Silberzan Pascal P Buguin Axel A Ladoux Benoit B Sheetz Michael P MP
Biophysical journal 20060818 10
Nonmuscle myosin IIA (NMM-IIA) is involved in the formation of focal adhesions and neurite retraction. However, the role of NMM-IIA in these functions remains largely unknown. Using RNA interference as a tool to decrease NMM-IIA expression, we have found that NMM-IIA is the major myosin involved in traction force generation and retrograde F-actin flow in mouse embryonic fibroblast cells. Quantitative analyses revealed that approximately 60% of traction force on fibronectin-coated surfaces is con ...[more]