Ontology highlight
ABSTRACT:
SUBMITTER: Hackbarth CJ
PROVIDER: S-EPMC163878 | biostudies-other | 1997 May
REPOSITORIES: biostudies-other
Hackbarth C J CJ Unsal I I Chambers H F HF
Antimicrobial agents and chemotherapy 19970501 5
A cosmid library from Mycobacterium tuberculosis H37Ra was introduced into Mycobacterium smegmatis, and eight recombinant clones with increased resistance to cefoxitin were identified. Isoelectric focusing detected an M. tuberculosis-derived beta-lactamase in one of these recombinant clones. A sequence analysis identified it as a class A beta-lactamase whose expression correlated with the increased resistance phenotype. ...[more]