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The redox protein construction kit: pre-last universal common ancestor evolution of energy-conserving enzymes.

ABSTRACT: Genome analyses and the resolution of three-dimensional structures have provided evidence in recent years for hitherto unexpected family relationships between redox proteins of very diverse enzymes involved in bioenergetic electron transport. Many of these enzymes appear in fact to be constructed from only a limited set of building blocks. Phylogenetic analysis of selected units from this "redox enzyme construction kit" indicates an origin for several prominent bioenergetic enzymes that is very early, lying before the divergence of Bacteria and Archaea. Possible scenarios for the early evolution of selected complexes are proposed based on the obtained tree topologies.

SUBMITTER: Baymann F

PROVIDER: S-EPMC1693098 | biostudies-other | 2003 Jan

REPOSITORIES: biostudies-other

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The redox protein construction kit: pre-last universal common ancestor evolution of energy-conserving enzymes.

Baymann Frauke F Lebrun Evelyne E Brugna Myriam M Schoepp-Cothenet Barbara B Giudici-Orticoni Marie-Thérèse MT Nitschke Wolfgang W

Philosophical transactions of the Royal Society of London. Series B, Biological sciences 20030101 1429

Genome analyses and the resolution of three-dimensional structures have provided evidence in recent years for hitherto unexpected family relationships between redox proteins of very diverse enzymes involved in bioenergetic electron transport. Many of these enzymes appear in fact to be constructed from only a limited set of building blocks. Phylogenetic analysis of selected units from this "redox enzyme construction kit" indicates an origin for several prominent bioenergetic enzymes that is very ...[more]

PMID: 12594934

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