Vascular endothelial growth factor-C accelerates diabetic wound healing.
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ABSTRACT:
SUBMITTER: Saaristo A
PROVIDER: S-EPMC1698814 | biostudies-other | 2006 Sep
REPOSITORIES: biostudies-other
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Vascular endothelial growth factor-C accelerates diabetic wound healing.
Saaristo Anne A Tammela Tuomas T Farkkilā Anniina A Kärkkäinen Marika M Suominen Erkki E Yla-Herttuala Seppo S Alitalo Kari K
The American journal of pathology 20060901 3
Diabetes impairs numerous aspects of tissue repair. Failure of wound angiogenesis is known to delay diabetic wound healing, whereas the importance of lymphangiogenesis for wound healing is unclear. We have examined whether overexpression of vascular endothelial growth factor (VEGF)-C via an adenoviral vector could improve the healing of full-thickness punch biopsy wounds in genetically diabetic (db/db) mice. We found that VEGF-C enhanced angiogenesis and lymphangiogenesis in the wound and signif ...[more]
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