Mapping a gene for adult-onset primary open-angle glaucoma to chromosome 3q.
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ABSTRACT:
SUBMITTER: Wirtz MK
PROVIDER: S-EPMC1712411 | biostudies-other | 1997 Feb
REPOSITORIES: biostudies-other
Publications
Mapping a gene for adult-onset primary open-angle glaucoma to chromosome 3q.
Wirtz M K MK Samples J R JR Kramer P L PL Rust K K Topinka J R JR Yount J J Koler R D RD Acott T S TS
American journal of human genetics 19970201 2
Glaucoma is the third-leading cause of blindness in the world, affecting >13.5 million people. Adult-onset primary open-angle glaucoma (POAG) is the most common form of glaucoma in the United States. We present a family in which adult-onset POAG is inherited as an autosomal dominant trait. Twelve affected family members were identified from 44 at-risk individuals. The disease-causing gene was mapped to chromosome 3q21-24, with analysis of recombinant haplotypes suggesting a total inclusion regio ...[more]
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