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Cloning and nucleotide sequence of a chromosomally encoded tetracycline resistance determinant, tetA(M), from a pathogenic, methicillin-resistant strain of Staphylococcus aureus.

ABSTRACT: This report describes the cloning and sequencing of a chromosomally encoded tetracycline resistance determinant from a clinical isolate of methicillin-resistant Staphylococcus aureus. On the basis of the sequence, the gene is in the tet(M) class, and it was shown that the S. aureus tetA(M) gene is induced at the level of transcription.

SUBMITTER: Nesin M

PROVIDER: S-EPMC172038 | biostudies-other | 1990 Nov

REPOSITORIES: biostudies-other

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Cloning and nucleotide sequence of a chromosomally encoded tetracycline resistance determinant, tetA(M), from a pathogenic, methicillin-resistant strain of Staphylococcus aureus.

Nesin M M Svec P P Lupski J R JR Godson G N GN Kreiswirth B B Kornblum J J Projan S J SJ

Antimicrobial agents and chemotherapy 19901101 11

This report describes the cloning and sequencing of a chromosomally encoded tetracycline resistance determinant from a clinical isolate of methicillin-resistant Staphylococcus aureus. On the basis of the sequence, the gene is in the tet(M) class, and it was shown that the S. aureus tetA(M) gene is induced at the level of transcription. ...[more]

PMID: 2073121

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