Ontology highlight
ABSTRACT:
SUBMITTER: Hines SA
PROVIDER: S-EPMC172999 | biostudies-other | 1995 Jan
REPOSITORIES: biostudies-other
Hines S A SA Palmer G H GH Jasmer D P DP Goff W L WL McElwain T F TF
Infection and immunity 19950101 1
Cattle immunized with a recombinant merozoite surface antigen-1 molecule (MSA-1) produced high-titered antibody that reacted with the surface of the parasite and neutralized merozoite infectivity in vitro. However, recombinant MSA-1 immunization did not confer protection against challenge with virulent Babesia bovis. These results indicate that antibody-mediated neutralization of merozoite infectivity in vitro, at least for MSA-1-specific antibody, does not reflect in vivo protective immunity to ...[more]