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Immunization of cattle with recombinant Babesia bovis merozoite surface antigen-1.


ABSTRACT: Cattle immunized with a recombinant merozoite surface antigen-1 molecule (MSA-1) produced high-titered antibody that reacted with the surface of the parasite and neutralized merozoite infectivity in vitro. However, recombinant MSA-1 immunization did not confer protection against challenge with virulent Babesia bovis. These results indicate that antibody-mediated neutralization of merozoite infectivity in vitro, at least for MSA-1-specific antibody, does not reflect in vivo protective immunity to babesiosis.

SUBMITTER: Hines SA 

PROVIDER: S-EPMC172999 | biostudies-other | 1995 Jan

REPOSITORIES: biostudies-other

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Immunization of cattle with recombinant Babesia bovis merozoite surface antigen-1.

Hines S A SA   Palmer G H GH   Jasmer D P DP   Goff W L WL   McElwain T F TF  

Infection and immunity 19950101 1


Cattle immunized with a recombinant merozoite surface antigen-1 molecule (MSA-1) produced high-titered antibody that reacted with the surface of the parasite and neutralized merozoite infectivity in vitro. However, recombinant MSA-1 immunization did not confer protection against challenge with virulent Babesia bovis. These results indicate that antibody-mediated neutralization of merozoite infectivity in vitro, at least for MSA-1-specific antibody, does not reflect in vivo protective immunity to  ...[more]

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