In vivo reversion to normal of inherited mutations in humans.
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ABSTRACT:
SUBMITTER: Hirschhorn R
PROVIDER: S-EPMC1735296 | biostudies-other | 2003 Oct
REPOSITORIES: biostudies-other
Publications
In vivo reversion to normal of inherited mutations in humans.
Journal of medical genetics 20031001 10
There are increasing reports of multiple different types of somatic mosaicism detected in patients with inherited and non-inherited disorders. The characteristics of several of the major types of mosaicism will be outlined, and contrasted with somatic mosaicism, which is the focus of this article. This review examines examples of somatic mosaicism due to differences in DNA sequence arising from in vivo site specific reversion to normal of inherited mutations in humans. While several known mechan ...[more]
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