Ontology highlight
ABSTRACT:
SUBMITTER: Li X
PROVIDER: S-EPMC1750900 | biostudies-other | 2006 Dec
REPOSITORIES: biostudies-other
Li Xi X Peng Yinghua Y Ren Jinsong J Qu Xiaogang X
Proceedings of the National Academy of Sciences of the United States of America 20061213 52
As the leading nanodevice candidate, single-walled carbon nanotubes (SWNTs) have potential therapeutic applications in gene therapy and novel drug delivery. We found that SWNTs can inhibit DNA duplex association and selectively induce human telomeric i-motif DNA formation by binding to the 5'-end major groove under physiological conditions or even at pH 8.0. SWNT binding to telomeric DNA was studied by UV melting, NMR, S1 nuclease cleavage, CD, and competitive FRET methods. These results suggest ...[more]