Ontology highlight
ABSTRACT:
SUBMITTER: Mullighan CG
PROVIDER: S-EPMC1754724 | biostudies-other | 2004 Jan
REPOSITORIES: biostudies-other
Mullighan C G CG Heatley S S Lester S S Rischmueller M M Gordon T P TP Bardy P G PG
Annals of the rheumatic diseases 20040101 1
<h4>Background</h4>Fas mediated apoptosis may be important in the pathogenesis of primary Sjögren's syndrome (pSS).<h4>Objective</h4>To examine genetic variation in the promoter region of the Fas gene in pSS.<h4>Methods</h4>Two single nucleotide polymorphisms at positions -1377(G/A) and -670(G/A) in the Fas gene promoter were genotyped by PCR-SSP in 101 patients with pSS and 108 Caucasoid controls.<h4>Results</h4>No significant differences in allele or genotype frequencies were detected between ...[more]