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Fas gene promoter polymorphisms in primary Sjogren's syndrome.

ABSTRACT: BACKGROUND: Fas mediated apoptosis may be important in the pathogenesis of primary Sjögren's syndrome (pSS). OBJECTIVE: To examine genetic variation in the promoter region of the Fas gene in pSS. METHODS: Two single nucleotide polymorphisms at positions -1377(G/A) and -670(G/A) in the Fas gene promoter were genotyped by PCR-SSP in 101 patients with pSS and 108 Caucasoid controls. RESULTS: No significant differences in allele or genotype frequencies were detected between the patients with pSS and controls. However, significant associations were observed with Ro/La autoantibody negative patients, who display milder and later onset disease. The -670A allele was more frequent in Ro/La autoantibody negative patients than in Ro/La autoantibody positive patients (p = 0.04). CONCLUSION: This study does not confirm an earlier report of an association between pSS and the Fas promoter -670G allele. However, the results suggest that genetically determined variability in Fas expression may modulate Ro/La autoantibody responses in patients with pSS.

SUBMITTER: Mullighan CG 

PROVIDER: S-EPMC1754724 | biostudies-other | 2004 Jan

REPOSITORIES: biostudies-other

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Fas gene promoter polymorphisms in primary Sjögren's syndrome.

Mullighan C G CG   Heatley S S   Lester S S   Rischmueller M M   Gordon T P TP   Bardy P G PG  

Annals of the rheumatic diseases 20040101 1

<h4>Background</h4>Fas mediated apoptosis may be important in the pathogenesis of primary Sjögren's syndrome (pSS).<h4>Objective</h4>To examine genetic variation in the promoter region of the Fas gene in pSS.<h4>Methods</h4>Two single nucleotide polymorphisms at positions -1377(G/A) and -670(G/A) in the Fas gene promoter were genotyped by PCR-SSP in 101 patients with pSS and 108 Caucasoid controls.<h4>Results</h4>No significant differences in allele or genotype frequencies were detected between  ...[more]

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