Differential immunogenicity of novel Mycobacterium tuberculosis antigens derived from live and dead bacilli.
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ABSTRACT:
SUBMITTER: Amara RR
PROVIDER: S-EPMC175702 | biostudies-other | 1997 Nov
REPOSITORIES: biostudies-other
Publications
Differential immunogenicity of novel Mycobacterium tuberculosis antigens derived from live and dead bacilli.
Amara R R RR Satchidanandam V V
Infection and immunity 19971101 11
Mouse serum raised against killed antigen preparations of Mycobacterium tuberculosis failed to recognize most of the recombinant antigens of M. tuberculosis that were originally identified by reactivity to tuberculosis (TB) patient sera. Similar results were obtained with serum from guinea pigs immunized with live and killed mycobacteria. Antibodies raised against seven random TB patient serum-reactive antigens detected each of these antigens in the sonicate preparation. The nucleotide sequences ...[more]
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