The mitogen-activated protein kinase homolog HOG1 gene controls glycerol accumulation in the pathogenic fungus Candida albicans.
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ABSTRACT:
SUBMITTER: San Jose C
PROVIDER: S-EPMC178437 | biostudies-other | 1996 Oct
REPOSITORIES: biostudies-other
Publications
The mitogen-activated protein kinase homolog HOG1 gene controls glycerol accumulation in the pathogenic fungus Candida albicans.
San José C C Monge R A RA Pérez-Díaz R R Pla J J Nombela C C
Journal of bacteriology 19961001 19
The Candida albicans HOG1 gene (HOG1CA) was cloned by functional complementation of the osmosensitive phenotype associated with Saccharomyces cerevisiae hog1 delta mutants. HOG1CA codes for a 377-amino-acid protein, 78% identical to S. cerevisiae Hog1p. A C. albicans hog1 null mutant was found to be sensitive to osmotic stress and failed to accumulate glycerol on high-osmolarity media. ...[more]
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