Ontology highlight
ABSTRACT:
SUBMITTER: Grebe T
PROVIDER: S-EPMC179116 | biostudies-other | 1997 May
REPOSITORIES: biostudies-other
Grebe T T Paik J J Hakenbeck R R
Journal of bacteriology 19970501 10
Piperacillin resistance in Streptococcus pneumoniae was mediated by mutations in a novel gene, cpoA, that also confer transformation deficiency and a decrease in penicillin-binding protein la. cpoA is part of an operon located downstream of the primary sigma factor of S. pneumoniae. The deduced protein, CpoA, and the peptide encoded by the adjacent 3' open reading frame contained domains homologous to glycosyltransferases of procaryotes and eucaryotes that act on membrane-associated substrates, ...[more]