Ontology highlight
ABSTRACT:
SUBMITTER: Castiglione CM
PROVIDER: S-EPMC1801414 | biostudies-other | 1995 Dec
REPOSITORIES: biostudies-other
Castiglione C M CM Deinard A S AS Speed W C WC Sirugo G G Rosenbaum H C HC Zhang Y Y Grandy D K DK Grigorenko E L EL Bonne-Tamir B B Pakstis A J AJ
American journal of human genetics 19951201 6
We present here the first evolutionary perspective on haplotypes at DRD2, the locus for the dopamine D2 receptor. The dopamine D2 receptor plays a critical role in the functioning of many neural circuits in the human brain. If functionally relevant variation at the DRD2 locus exists, understanding the evolution of haplotypes on the basis of polymorphic sites encompassing the gene should provide a powerful framework for identifying that variation. Three DRD2 polymorphisms (TaqI "A" and "B" RFLPs ...[more]