Ontology highlight
ABSTRACT:
SUBMITTER: Katanaev VL
PROVIDER: S-EPMC1820807 | biostudies-other | 2007 Jan
REPOSITORIES: biostudies-other
Katanaev Vladimir L VL Chornomorets Matey M
The Biochemical journal 20070101 2
The majority of intracellular signalling cascades in higher eukaryotes are initiated by GPCRs (G-protein-coupled receptors). Hundreds of GPCRs signal through a handful of trimeric G-proteins, raising the issue of signal specificity. In the present paper, we illustrate a simple kinetic model of G-protein signalling. This model shows that stable production of significant amounts of free Galpha(GTP) (GTP-bound Galpha subunit) and betagamma is only one of multiple modes of behaviour of the G-protein ...[more]