Ontology highlight
ABSTRACT:
SUBMITTER: Saito T
PROVIDER: S-EPMC1866207 | biostudies-other | 2007 May
REPOSITORIES: biostudies-other
Saito Taku T Ikeda Toshiyuki T Nakamura Kozo K Chung Ung-il UI Kawaguchi Hiroshi H
EMBO reports 20070330 5
Transcription factor SOX9 (sex-determining region Y-type high mobility group box 9) and its coactivators SOX5 and SOX6 (the SOX trio) induce early-stage chondrocyte differentiation and suppress its terminal stage. To identify possible targets of the SOX trio, we carried out a microarray analysis and identified S100A1 and S100B as possible target molecules. S100 protein expression was localized in late proliferative and pre-hypertrophic chondrocytes of the mouse growth plate. Overexpression of S1 ...[more]