Ontology highlight
ABSTRACT:
SUBMITTER: Pigolotti S
PROVIDER: S-EPMC1871820 | biostudies-other | 2007 Apr
REPOSITORIES: biostudies-other
Pigolotti Simone S Krishna Sandeep S Jensen Mogens H MH
Proceedings of the National Academy of Sciences of the United States of America 20070405 16
Organisms are equipped with regulatory systems that display a variety of dynamical behavior ranging from simple stable steady states, to switching and multistability, to oscillations. Earlier work has shown that oscillations in protein concentrations or gene expression levels are related to the presence of at least one negative feedback loop in the regulatory network. Here, we study the dynamics of a very general class of negative feedback loops. Our main result is that, when a single negative f ...[more]