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Tetracycline resistance determinants in Mycobacterium and Streptomyces species.


ABSTRACT: Two of seven tetracycline-resistant (Tcr) Mycobacterium fortuitum group isolates and six Tcr clinical Streptomyces isolates carried gram-positive Tcr determinants (Tet K and Tet L) and Streptomyces resistance determinants (Otr A, Otr B, and Otr C). This represents the first documentation of the acquisition by mycobacteria of determinants coding for antibiotic resistance and suggests the potential for the spread of antibiotic resistance determinants within mycobacterial species.

SUBMITTER: Pang Y 

PROVIDER: S-EPMC188220 | biostudies-other | 1994 Jun

REPOSITORIES: biostudies-other

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Tetracycline resistance determinants in Mycobacterium and Streptomyces species.

Pang Y Y   Brown B A BA   Steingrube V A VA   Wallace R J RJ   Roberts M C MC  

Antimicrobial agents and chemotherapy 19940601 6


Two of seven tetracycline-resistant (Tcr) Mycobacterium fortuitum group isolates and six Tcr clinical Streptomyces isolates carried gram-positive Tcr determinants (Tet K and Tet L) and Streptomyces resistance determinants (Otr A, Otr B, and Otr C). This represents the first documentation of the acquisition by mycobacteria of determinants coding for antibiotic resistance and suggests the potential for the spread of antibiotic resistance determinants within mycobacterial species. ...[more]

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