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A Bacteroides tetracycline resistance gene represents a new class of ribosome protection tetracycline resistance.

ABSTRACT: The ribosome protection type of tetracycline resistance (Tcr) has been found in a variety of bacterial species, but the only two classes described previously, Tet(M) and Tet(O), shared a high degree of amino acid sequence identity (greater than 75%). Thus, it appeared that this type of resistance emerged recently in evolution and spread among different species of bacteria by horizontal transmission. We obtained the DNA sequence of a Tcr gene from Bacteroides, a genus of gram-negative, obligately anaerobic bacteria that is phylogenetically distant from the diverse species in which tet(M) and tet(O) have been found. The Bacteroides Tcr gene defines a new class of ribosome protection resistance genes, Tet(Q), and has a deduced amino acid sequence that was only 40% identical to Tet(M) or Tet(O). Like tet(M) and tet(O), tet(Q) appears to have spread by horizontal transmission, but only within the Bacteroides group.

SUBMITTER: Nikolich MP

PROVIDER: S-EPMC188826 | biostudies-other | 1992 May

REPOSITORIES: biostudies-other

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A Bacteroides tetracycline resistance gene represents a new class of ribosome protection tetracycline resistance.

Nikolich M P MP Shoemaker N B NB Salyers A A AA

Antimicrobial agents and chemotherapy 19920501 5

The ribosome protection type of tetracycline resistance (Tcr) has been found in a variety of bacterial species, but the only two classes described previously, Tet(M) and Tet(O), shared a high degree of amino acid sequence identity (greater than 75%). Thus, it appeared that this type of resistance emerged recently in evolution and spread among different species of bacteria by horizontal transmission. We obtained the DNA sequence of a Tcr gene from Bacteroides, a genus of gram-negative, obligately ...[more]

PMID: 1339256

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