Ontology highlight
ABSTRACT:
SUBMITTER: Caulin C
PROVIDER: S-EPMC1904325 | biostudies-other | 2007 Jul
REPOSITORIES: biostudies-other
Caulin Carlos C Nguyen Thao T Lang Gene A GA Goepfert Thea M TM Brinkley Bill R BR Cai Wei-Wen WW Lozano Guillermina G Roop Dennis R DR
The Journal of clinical investigation 20070701 7
Mutations in ras and p53 are the most prevalent mutations found in human nonmelanoma skin cancers. Although some p53 mutations cause a loss of function, most result in expression of altered forms of p53, which may exhibit gain-of-function properties. Therefore, understanding the consequences of acquiring p53 gain-of-function versus loss-of-function mutations is critical for the generation of effective therapies for tumors harboring p53 mutations. Here we describe an inducible mouse model in whic ...[more]