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Sequence analysis of the human DNA flanking sites of human immunodeficiency virus type 1 integration.

ABSTRACT: Human immunodeficiency virus type 1 (HIV-1) tagged with the Escherichia coli supF gene has been used to clone integrated HIV-1 proviruses. Sequence analysis of the 600 to 800 bp of human DNA adjacent to 29 clones revealed a propensity for HIV-1 to integrate near the Alu class of human repetitive elements.

SUBMITTER: Stevens SW 

PROVIDER: S-EPMC190680 | biostudies-other | 1996 Sep

REPOSITORIES: biostudies-other

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Sequence analysis of the human DNA flanking sites of human immunodeficiency virus type 1 integration.

Stevens S W SW   Griffith J D JD  

Journal of virology 19960901 9

Human immunodeficiency virus type 1 (HIV-1) tagged with the Escherichia coli supF gene has been used to clone integrated HIV-1 proviruses. Sequence analysis of the 600 to 800 bp of human DNA adjacent to 29 clones revealed a propensity for HIV-1 to integrate near the Alu class of human repetitive elements. ...[more]

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