Ontology highlight
ABSTRACT:
SUBMITTER: Schachtrup C
PROVIDER: S-EPMC1913857 | biostudies-other | 2007 Jul
REPOSITORIES: biostudies-other
Schachtrup Christian C Lu Paul P Jones Leonard L LL Lee Jae K JK Lu Jerry J Sachs Ben D BD Zheng Binhai B Akassoglou Katerina K
Proceedings of the National Academy of Sciences of the United States of America 20070702 28
Changes in the molecular and cellular composition of the CNS after injury or disease result in the formation of an inhibitory environment that inhibits the regeneration of adult mammalian CNS neurons. Although a dramatic change in the CNS environment after traumatic injury or disease is hemorrhage because of vascular rupture or leakage of the blood-brain barrier, the potential role for blood proteins in repair processes remains unknown. Here we show that the blood protein fibrinogen is an inhibi ...[more]