A ratiometric lectin microarray approach to analysis of the dynamic mammalian glycome.
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ABSTRACT:
SUBMITTER: Pilobello KT
PROVIDER: S-EPMC1913879 | biostudies-other | 2007 Jul
REPOSITORIES: biostudies-other
Publications
A ratiometric lectin microarray approach to analysis of the dynamic mammalian glycome.
Pilobello Kanoelani T KT Slawek Deepika E DE Mahal Lara K LK
Proceedings of the National Academy of Sciences of the United States of America 20070702 28
Glycosylation creates an intricate and complex code for biological information that plays a role in cell-cell communication, infection, and immunity among many biological events. Dynamic changes in the glycosylation status of cells have been observed in tumor cell metastasis and cell differentiation but have been difficult to analyze because of a lack of high-throughput and facile technologies. Here, we present a method for the rapid evaluation of differences in the glycosylation of heterogeneou ...[more]
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