Ontology highlight
ABSTRACT:
SUBMITTER: Tahk S
PROVIDER: S-EPMC1913887 | biostudies-other | 2007 Jul
REPOSITORIES: biostudies-other
Tahk Samuel S Liu Bin B Chernishof Vasili V Wong Kelly A KA Wu Hong H Shuai Ke K
Proceedings of the National Academy of Sciences of the United States of America 20070702 28
NF-kappaB and STATs regulate multiple cellular processes through the transcriptional activation of genes with diversified functions. Although the molecular mechanisms that can turn on/off the overall NF-kappaB/STAT signaling have been extensively studied, how NF-kappaB/STAT-target genes can be differentially regulated is poorly understood. Here we report that PIASy, a member of the PIAS (for protein inhibitor of activated STAT) protein family, is a physiologically important transcriptional repre ...[more]